ANZMTG 04.12 REFORM - Radiotherapy followed by selective nodal dissection for high volume regional melanoma: A phase II trial -- ON HOLD

Currently there is no standard treatment approach for patients with high volume nodal melanoma. Most patients receive up front surgery and generally receive adjuvant radiotherapy. Irrespective of the approach both radiotherapy and surgery are commonly used but the order of these two modalities is at the treating clinicians’ discretion. This is a phase II trial of radiotherapy followed by selective nodal dissection in patients presenting with high volume regional nodal melanoma. The primary objective of this study is to investigate the1-year major complication free nodal control rate

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Proposed Trial - ANZMTG 02.13 A randomised phase II study of immunotherapy with DPCP treated autologous melanoma vaccines -- ON HOLD

Previous studies have suggested that immunotherapy with chemically coated (haptenized) autologous melanoma cells may be associated with regression of metastases and increased relapse free survival (RFS) in patients with AJCC stage IV and inoperable stage III melanoma. This study aims to further explore the possible efficacy of this approach in patients with melanoma with minimal disease following surgery or treatment with selective BRAF inhibitors.

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Proposed Trial - ANZMTG 03.13 A randomized controlled trial in T1N0 Merkel Cell Carcinoma of either radiotherapy to the primary site or wide local excision following diagnostic biopsy -- ON HOLD

ANZMTG 03.14 PRISM Prospective multisite evaluation of the roles of18F-FDG PET and Sentinel lymph node mapping ? biopsy in the diagnostic workup of Merkel Cell carcinoma

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ANZMTG 01.15 CHARLI

A Phase II Trial of Ipilimumab-Nivolumab-Denosumab and Nivolumab-Denosumab in Patients with Unresectable Stage III and IV Melanoma (Short Title: CHARLI (Checkpoint And RANK-L Inhibition))

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ANZMTG 02.15 Merkel Cell Carcinoma

A randomised controlled trial in T1N0 Merkel Cell Carcinoma of either radiotherapy to the primary site or wide local excision following diagnostic biopsy

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